Maryland's Defense Patent Database

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Artemisinins with improved stability and bioavailability for therapeutic drug development and application

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MRDC

A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.

Inventors: 
Hartell, Mark G.; Bhattacharjee, Apurba K.; Hicks, Rickey P.; Vanhamont, John E.; Milhous, Wilbur K.
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2003-02-27
Grant Date: 
2005-10-04
Grant time: 
950 days
Grant time percentile rank: 
17
Claim count percentile rank: 
7
Citations percentile rank: 
1
'Cited by' percentile rank: 
2
Assignee: 
US ARMY