Maryland's Defense Patent Database

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Vaccine against Gram-negative bacterial infections

Patent image
AMRMC

A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

Inventors: 
Bhattacharjee, Apurba; Cross, Alan; Sadoff, Jerald; Zollinger, Wendell
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
1995-06-06
Grant Date: 
2006-04-11
Grant time: 
3,962 days
Grant time percentile rank: 
71
Claim count percentile rank: 
1
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY