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Plasmodium falciparum AMA-1 protein and uses thereof

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MRDC

In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.

Inventors: 
Lanar, David E.; Dutta, Sheetij; Ware, Lisa A.; Nair V, Lalitha P.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2002-10-15
Grant Date: 
2006-04-18
Grant time: 
1,281 days
Grant time percentile rank: 
23
Claim count percentile rank: 
6
Citations percentile rank: 
1
'Cited by' percentile rank: 
2
Assignee: 
US ARMY