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Internal positive control for probe-based nucleic acid molecule assays and methods of making and using thereof

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AMRMC

Disclosed herein are isolated nucleic acid molecules that may be used as an internal positive controls in probe-based nucleic acid assays such as TaqMan® based assays. Also disclosed are probes comprising the isolated nucleic acid molecule of the present invention. The probes may comprise a reporter molecule and a quencher molecule. Also disclosed are assays which comprise using the probe of the present invention. The probes may be used to distinguish false negative results from true negative results in assays for a target nucleic acid molecule. The probe may be used in conjunction with probe-based nucleic acid assays for the detection of an organism such as one belonging to Bacillus, Mycobacterium, Francisella, Brucella, Clostridium, Yersinia, Variola, Orthopox, or Burkholderia.

Inventors: 
Hartman, Laurie J.; Norwood Jr., David A.; Wasieloski Jr., Leonard P.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2004-12-22
Grant Date: 
2006-05-30
Grant time: 
524 days
Grant time percentile rank: 
9
Claim count percentile rank: 
6
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY