Maryland's Defense Patent Database

The defense community in Maryland is an R&D powerhouse.

Use this database to see the innovative patents that are poised for commercialization.

Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides

Patent image
AMRMC

An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccaride and formulated in accordance with the current invention for mucosal delivery such as via the oral or intranasal route is used as a vaccine. Specifically, a vaccine using shigella lipopolysaccharides complexed to proteosomes for such mucosal administration induces IgG and IgA antibodies in sera and in respiratory and intestinal fluids. Furthermore, such antibodies are associated with protection against shigella infection and these vaccines are herein demonstrated to protect against mucosal infection with shigella.

Inventors: 
Lowell, George H.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
1992-10-08
Grant Date: 
2006-09-26
Grant time: 
5,101 days
Grant time percentile rank: 
86
Claim count percentile rank: 
6
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY