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Extraneous DNA sequence that facilitates hantavirus gene expression

Patent image
AMRMC

In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.

Inventors: 
Hooper, Jay W.; Schmaljohn, Connie S.; Custer, Max
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2003-03-21
Grant Date: 
2007-05-15
Grant time: 
1,516 days
Grant time percentile rank: 
27
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY