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Recombinant P. falciparum merozoite protein-142 vaccine

Patent image
AMRMC

In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Inventors: 
Lyon, Jeffrey A.; Angov, Evelina; Cohen, Joe D.; Voss, Gerald
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2002-01-25
Grant Date: 
2007-12-11
Grant time: 
2,146 days
Grant time percentile rank: 
39
Claim count percentile rank: 
4
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY