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Cloning and expression of the full length 110 kDa antigen of <i>Orientia tsutsugamushi </i>to be used as a vaccine component against scrub typhus

Patent image
NMRC

The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein of O. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response against O. tsutsugamuchi invection using. The inventive subject matter also relates to a recombinant 110 kDa O. tsutsugamuchi protein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.

Inventors: 
Ching, Wei-mei; Chao, Chien-chung
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2005-04-19
Grant Date: 
2008-05-13
Grant time: 
1,120 days
Grant time percentile rank: 
20
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US NAVY