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Isolation and purification of <i>P. falciparum </i>merozoite protein-142 vaccine

Patent image
AMRMC

In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Inventors: 
Lyon, Jeffrey A.; Angov, Evelina
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2005-01-24
Grant Date: 
2009-09-29
Grant time: 
1,709 days
Grant time percentile rank: 
31
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY