Maryland's Defense Patent Database

The defense community in Maryland is an R&D powerhouse.

Use this database to see the innovative patents that are poised for commercialization.

Design and selection of genetic targets for sequence resolved organism detection and identification

Patent image

A computer-implemented method as follows. Providing a list of target sequences associated with one or more organisms. Providing a list of candidate prototype sequences suspected of hybridizing to one or more of the target sequences. Generating a collection of probes corresponding to each candidate prototype sequence, each collection of probes having a set of probes for every subsequence. The sets consist of the corresponding subsequence and every variation of the corresponding subsequence formed by varying a center nucleotide of the corresponding subsequence. Generating a set of fragments corresponding to each target sequence. Calculating the binding free energy of each fragment with a perfect complimentary sequence of the fragment. Determining which extended fragments are perfect matches to any of the probes. Assembling a base call sequence corresponding to each candidate prototype sequence.

Malanoski, Anthony P.; Wang, Zheng; Lin, Baochuan; Stenger, David A.; Schnur, Joel M.
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
Grant Date: 
Grant time: 
916 days
Grant time percentile rank: 
Claim count percentile rank: 
Citations percentile rank: 
'Cited by' percentile rank: