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Screening methods using normal human liver cell line

Patent image
AMRMC

In this application is described the establishment and maintenance of a normal human hepatocyte cell line able to support complete development of malaria parasite development in vitro. The cell line can be used in methods for screening compounds affecting normal human liver cells or normal human cells infected with malaria parasites, measuring uptake of drugs or chemicals into normal human liver cells, and measuring metabolism of a drug in a normal human liver cell. Other advantages and uses of the cell line are also described.

Inventors: 
Prachumsri, Jetsumon; Yimamnuaychok, Nongnuch
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2006-01-19
Grant Date: 
2010-08-24
Grant time: 
1,678 days
Grant time percentile rank: 
30
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY