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Electrochemical biosensors, applications and methods of making biosensors

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ARL

Electrochemical biosensors, methods of making biosensors and methods of detecting a target analyte in a sample to be analyzed are provided. A preferred embodiment device comprises a non-conductive polymer deposited on the electrode to form a matrix material having a plurality of pores; a capture biomolecule immobilized on the electrode such that the binding of the target analyte to the capture biomolecule effectively blocks a sufficient number of pores in the matrix material to produce a measurable decrease in the rate of a redox reaction occurring at the electrode; a current source for driving a redox reaction at the electrode; a redox species in contact with the electrode; and a detector element operatively connected to the electrode to detect the measureable decrease of a change in the rate of a redox reaction occurring due to the blockage of pores in the matrix material by the target analyte.

Inventors: 
Sumner, James J.
Patent Number: 
Technical domain: 
Sensors and Measurement
FIle Date: 
2005-11-15
Grant Date: 
2011-02-22
Grant time: 
1,925 days
Grant time percentile rank: 
35
Claim count percentile rank: 
6
Citations percentile rank: 
2
'Cited by' percentile rank: 
1
Assignee: 
US ARMY