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Methods for downregulating CCR5 in T cells with anti-CD3 antibodies and anti-CD28 antibodies

Patent image
NMRC

Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.

Inventors: 
June, Carl H.; Carroll, Richard G.; Riley, James L.; St. Louis, Daniel C.; Levine, Bruce L.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
1998-02-20
Grant Date: 
2011-04-19
Grant time: 
4,806 days
Grant time percentile rank: 
83
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY