Maryland's Defense Patent Database

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Anti-microbial peptidomimetic compounds and methods to calculate anti-microbial activity

Patent image
MRDC

This invention encompasses synthetic antimicrobial peptide analogs having certain un-natural amino acids, including the un-natural amino acids hydrophobic tetrahydroisoquinolinecarboxylic acid (Tic) and octahydroindolecarboxylic acid (Oic), incorporated into the polypeptide backbone. These antimicrobial peptides (AMPs) are useful to treat infection in humans and other mammals of such bacteria as Gram positive bacteria, Gram negative bacteria and Mycobacterium. Many of the AMPs also exhibit the property of reduced hemolytic activity. The invention also entails 3D-QSAR models and mathematical equations that calculate the biological activity of any peptide sequence against Staphylococcus aureus or Mycobacterium ranae.

Inventors: 
Hicks, Rickey P.; Venugopal, Diva Karamenon; Bhonsle, Jayendra
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2007-12-20
Grant Date: 
2012-05-29
Grant time: 
1,622 days
Grant time percentile rank: 
29
Claim count percentile rank: 
5
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY