Maryland's Defense Patent Database

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Direct quantification of ribosome inactivating protein

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A method for detecting ribosome inactivating protein (RIP) activity in a sample is provided that involves contacting a sample that contains an RIP with an inventive substrate that is depurinated to form product. The product is hybridized to a template and cleaved by an apurinic/apyrimidinic endonuclease such that releasing the blocked 3′ end only in a sample that contains RIP activity. The 5′ end of the product serves as a primer for extension by a polymerase reaction. The newly synthesized strand complementary to the template is detected by RT-PCR processes. A kit is provided suitable for field or laboratory use.

Inventors: 
Dorsey, Russell M.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2010-06-28
Grant Date: 
2012-05-29
Grant time: 
701 days
Grant time percentile rank: 
12
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY