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Recombinant <i>P. falciparum </i>merozoite protein-142 vaccine

Patent image
AMRMC

In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-142. The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Inventors: 
Angov, Evelina; Lyon, Jeffrey A.; Darko, Christian Asare; Cohen, Joe D.
Patent Number: 
Technical domain: 
Sensors and Measurement
FIle Date: 
2009-07-21
Grant Date: 
2012-07-03
Grant time: 
1,078 days
Grant time percentile rank: 
19
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY