Maryland's Defense Patent Database

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Induction of an immune response against dengue virus using the prime-boost approach

Patent image
NMRC

The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprises administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins.

Inventors: 
Simmons, Monika; Porter, Kevin R.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2007-11-02
Grant Date: 
2012-08-14
Grant time: 
1,747 days
Grant time percentile rank: 
32
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY