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<i>Plasmodium </i>liver stage antigens

Patent image
AMRMC

The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.

Inventors: 
Duffy, Patrick; Kappe I, Stefan H.; Krzych, Urszula; Heppner, Donald G.; Bergman, Lawrence W.; Malkov, Vladislav A.; Tarun, Alice; Wendler, Jason P.; Bacik, Igor
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2010-03-11
Grant Date: 
2012-11-27
Grant time: 
992 days
Grant time percentile rank: 
18
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
SEATTLE BIOMEDICAL RES INST; US ARMY; PHILADELPHIA HEALTH & EDUCATION CORP