Maryland's Defense Patent Database

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Malaria antigen screening method

Patent image
NMRC

The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.

Inventors: 
Bruder, Joseph T.; Kovesdi, Imre; Mcvey, Duncan L.; Brough, Douglas E.; King, Richter C.; Doolan, Denise Louise; Aguair, Joao Carlos; Carucci, Daniel John; Sedegah, Martha; Weiss, Walter R.; Limbach, Keith
Patent Number: 
Technical domain: 
Sensors and Measurement
FIle Date: 
2006-08-25
Grant Date: 
2013-05-28
Grant time: 
2,468 days
Grant time percentile rank: 
45
Claim count percentile rank: 
4
Citations percentile rank: 
2
'Cited by' percentile rank: 
1
Assignee: 
US NAVY