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DNA immunogenic composition comprising a full-length modified poxvirus L1R gene fused to a tPA leader sequence

Patent image
AMRMC

The invention described here encompasses DNA and protein vaccines against poxviruses, and relevant immunogenic compositions, comprising at a minimum a nucleic acid encoding a modified full-length poxvirus L1R gene or its ortholog. The L1R gene is modified so that an endoplasmic reticulum-targeting sequence is operably linked on the 5′ end. Preferably the nucleic acid sequences for other poxviruses antigens are also included, such as A33R, B5R and/or A27L. These vaccines and compositions provide improved neutralizing antibody response elicited by molecular poxvirus vaccines, over known vaccines using unmodified L1R.

Inventors: 
Hooper, Jay W.; Golden, Joseph W.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2008-07-07
Grant Date: 
2013-08-20
Grant time: 
1,870 days
Grant time percentile rank: 
34
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY