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Tissue graft with non-aligned fiber matrix retains mesenchymal progenitor cells on the non-injury-facing side

Patent image
AMRMC

A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.

Inventors: 
Jackson, Wesley M.; Nesti, Leon J.; Tuan, Rocky S.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2009-08-05
Grant Date: 
2014-02-18
Grant time: 
1,658 days
Grant time percentile rank: 
30
Claim count percentile rank: 
7
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY