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Affinity-based detection of biological targets

Patent image
NRL

A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.

Inventors: 
Kulagina, Nadezhda V.; Taitt, Chris Rowe; Anderson, George P.; Ligler, Frances S.
Patent Number: 
Technical domain: 
Sensors and Measurement
FIle Date: 
2006-02-06
Grant Date: 
2014-02-25
Grant time: 
2,941 days
Grant time percentile rank: 
54
Claim count percentile rank: 
4
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US NAVY