Maryland's Defense Patent Database

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Puumala virus full-length M segment-based DNA vaccines

Patent image
AMRMC

The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was cloned into a plasmid to form the first stable PUUV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a molecular vaccine system, and is useful to protect mammals against infection with Puumala virus.

Inventors: 
Hooper, Jay
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2012-04-11
Grant Date: 
2014-10-07
Grant time: 
909 days
Grant time percentile rank: 
16
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY