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Automated sample-to-microarray apparatus and method

Patent image
NRL

An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a microarray and a liquid in contact with the microarray. The apparatus is configured to be coupled to a device for: pumping a liquid through, in order, the lysis, purification, thermocycling, fragmentation, and microarray modules; sonicating any contents of the lysis module; thermocycling the thermocycling module to perform the polymerase chain reaction; heating the fragmentation module to fragment any oligonucleotides contained therein; circulating a fluid over the surface of the microarray; and performing one or more washing or staining steps on the microarray.

Inventors: 
Ligler, Frances S.; Stenger, David A.; Erickson, Jeff; Archer, Marie
Patent Number: 
Technical domain: 
Chemical engineering
FIle Date: 
2006-11-14
Grant Date: 
2015-02-24
Grant time: 
3,024 days
Grant time percentile rank: 
55
Claim count percentile rank: 
4
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US NAVY