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Solid phase for capture of nucleic acids

Patent image
NRL

A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.

Inventors: 
Archer, Marie J.; Lin, Baochuan; Stenger, David A.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2007-05-21
Grant Date: 
2015-08-04
Grant time: 
2,997 days
Grant time percentile rank: 
55
Claim count percentile rank: 
5
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US NAVY