Maryland's Defense Patent Database

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Adhesin-enterotoxin chimera based immunongenic composition against enterotoxigenic <i>Escherichia coli</i>

Patent image
NMRC

The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.

Inventors: 
Savarino, Stephen J.; Holmes, Randall K.; Jobling, Michael G.
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2007-01-11
Grant Date: 
2015-08-18
Grant time: 
3,141 days
Grant time percentile rank: 
57
Claim count percentile rank: 
11
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
UNIV COLORADO