Maryland's Defense Patent Database

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Plasmodium falciparum circumsporozoite vaccine gene optimization for soluble protein expression

Patent image
MRDC

The present invention provides novel nucleotide sequence and other constructs used for expression of novel recombinant P. falciparum circumsporozoite proteins in bacterial cells such as E. coli. Processes are provided for producing a soluble recombinant P. falciparum CSP from E. coli. Methods to produce a human-grade, highly immunogenic anti-malaria vaccine based on CSP are shown. The novel recombinant P. falciparum circumsporozoite protein by itself or in combination with other malaria antigens or adjuvants can form the basis of an effective malaria vaccine.

Inventors: 
Dutta, Sheetij
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2011-10-18
Grant Date: 
2015-08-25
Grant time: 
1,407 days
Grant time percentile rank: 
25
Claim count percentile rank: 
6
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY