Maryland's Defense Patent Database

The defense community in Maryland is an R&D powerhouse.

Use this database to see the innovative patents that are poised for commercialization.

Ricin vaccine and methods of making thereof

Patent image
MRDC

Disclosed herein ricin toxin A chain polypeptides having an engineered disulfide bond ((SS)RTA) and compositions thereof. The disclosed (SS)RTA polypeptides retain the immunological epitope of wild type RTA, lack detectable N-glycosidase activity or exhibit reduced N-glycosidase activity as compared to controls, and exhibit increased solubility, thermal stability and a lower tendency to self-aggregate as compared to RTA 198 and/or RTA 1-33/44-198. Also disclosed are immunogenic compositions that may be used to immunize a subject against ricin intoxication. Methods of immunizing against, treating, inhibiting, reducing and/and preventing ricin intoxication are disclosed.

Inventors: 
Legler, Patricia M.; Compton, Jaimee R.; Millard, Charles B.; Olson, Mark A.
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2011-04-21
Grant Date: 
2015-09-15
Grant time: 
1,608 days
Grant time percentile rank: 
29
Claim count percentile rank: 
5
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY