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This mobile sample isolation and containment system is designed to provide a chemical and biological screening and verification capability within an environmentally-controlled area while minimizing exposure of analytical instruments to contamination. Only those parts of the analytical instrument absolutely necessary for retrieving sample information are disposed within the potentially contaminated enclosure, while other electrical or optical components remain outside said enclosure. The system uses multiple technologies that target, interrogate, and describe the same sample. Therefore, an analyst will not need to remove a hazardous sample from containment before it is identified.