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Nucleic acids containing a synthetic codon-optimized Sin Nombre virus full-length M gene

Patent image
AMRMC

The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.

Inventors: 
Hooper, Jay
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2011-01-31
Grant Date: 
2016-04-19
Grant time: 
1,905 days
Grant time percentile rank: 
35
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
GOVERNMENT OF THE UNITED STATES AS REP BY SECY OF THE ARMY FOR US ARMY MEDICAL RES INST