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Combinations of gene deletions for live attenuated shigella vaccine strains

Patent image
AMRMC

Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (ΔsenA, ΔsenB, ΔvirG, ΔmsbB2), WRSf2G15 (ΔvirG, ΔsetAB, ΔsenA, ΔsenB, ΔmsbB2), and WRSd5 (ΔvirG, ΔstxAB, ΔsenA, ΔsenB, ΔmsbB2).

Inventors: 
Venkatesan, Malabi; Ranallo, Ryan; Barnoy, Shoshana
Patent Number: 
Technical domain: 
Biotechnology and Healthcare
FIle Date: 
2015-02-23
Grant Date: 
2016-04-26
Grant time: 
428 days
Grant time percentile rank: 
7
Claim count percentile rank: 
5
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY