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The system in at least one embodiment includes a tamper evident specimen sample locking device that in a further embodiment includes an embedded data storage mechanism. A method for using the system in at least one embodiment allows for efficiently and securely creating, maintaining, identifying, tracking, and controlling inventories (either prospective or retrospective) of biological and chemical sample containers and their contents, while eliminating potential loss and degradation associated with handling the samples. The system in at least one embodiment includes a sample container tray or cryogenic box having one or more integrated RFID readers within an associated smart lid that sense RFIDs associated with the individual samples thereby eliminating the need to remove, visually inspect, and/or handle the samples.