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Multivalent meningococcal conjugates and methods for preparing conjugates

Patent image
AMRMC

Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.

Inventors: 
Lee, Che-hung Robert; Pinto, Valerian B.
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2013-05-23
Grant Date: 
2016-08-30
Grant time: 
1,195 days
Grant time percentile rank: 
21
Claim count percentile rank: 
2
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US ARMY