Maryland's Defense Patent Database

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Allograft tolerance induction

Patent image
NMRC

A method inducing chimerism and allograft tolerance by co-infusion of stem/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system.

Inventors: 
Davis, Thomas A.; Anam, Khairul; Elster, Eric A.; Tadaki, Douglas K.
Patent Number: 
Technical domain: 
Materials and Coatings
FIle Date: 
2014-03-14
Grant Date: 
2016-10-04
Grant time: 
935 days
Grant time percentile rank: 
17
Claim count percentile rank: 
3
Citations percentile rank: 
1
'Cited by' percentile rank: 
1
Assignee: 
US NAVY